Merestinib [CAS 1206799-15-6]

Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) [1][2].

[1206799-15-6]

C30H22F2N6O3

552.53

O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3

C-Met/HGFR; Discoidin Domain Receptor; FLT3; ROS Kinase

99.99

DMSO : ≥ 32 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H317, H318, H334, H335, H341, H361, H370, H413

H315, H317, H318, H334, H335, H341, H361, H370, H413