Metallo-β-lactamase-IN-11

Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM) . Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance[1].

C31H23N3O

453.53

N#CC1=C(/N=C/C2=CC=C(O)C=C2)N(CC3=CC=CC=C3)C(C4=CC=CC=C4)=C1C5=CC=CC=C5

Bacterial; Beta-lactamase

10 mM in DMSO

Room temperature