Methiothepin (maleate) [CAS 19728-88-2]

Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C) .

[19728-88-2]

C24H28N2O4S2

472.62

CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1.OC(/C=C\C(O)=O)=O

5-HT Receptor

5-HT1 Receptor;5-HT2 Receptor;5-HT5 Receptor;5-HT6 Receptor;5-HT7 Receptor

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501