Methotrexate metabolite [CAS 19741-14-1]
Methotrexate metabolite [CAS 19741-14-1]
SKU:QM-0112919-01
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Product Details
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Description
Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation[2][3].
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CAS Number
[19741-14-1]
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Molecular Formula
C15H15N7O2
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Molecular Weight
325.33
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Smiles
O=C(O)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1
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Target
Antifolate; Dihydrofolate reductase (DHFR) ; Drug Metabolite; Parasite
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Purity
98.44
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Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H315, H319, H341, H360
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Precautions
H301, H315, H319, H341, H360
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Methotrexate metabolite [CAS 19741-14-1]
Methotrexate metabolite is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.