α, β-Methylene-ATP (dilithium) [CAS 104809-20-3]
α, β-Methylene-ATP (dilithium) [CAS 104809-20-3]
SKU:QM-0144731
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Product Details
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Description
α, β-Methylene-ATP dilithium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α, β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC) ; this effect can be blocked by the P2X antagonist PPADS. α, β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α, β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system[1][2][3].
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CAS Number
[104809-20-3]
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Molecular Formula
C11H18Li2N5O12P3
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Molecular Weight
519.09
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Smiles
OP(OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)(O)=O)(O)=O.[Li].[Li]
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Target
P2X Receptor
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Isoform
P2X1 Receptor; P2X3 Receptor; P2X7 Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H335
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Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
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α, β-Methylene-ATP (dilithium) [CAS 104809-20-3]
α, β-Methylene-ATP (dilithium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.