α, β-Methylene-ATP (trisodium) [CAS 1343364-54-4]
α, β-Methylene-ATP (trisodium) [CAS 1343364-54-4]
SKU:QM-0136186-01
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Product Details
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Description
α, β-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α, β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC) ; this effect can be blocked by the P2X antagonist PPADS. α, β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α, β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system[1][2][3].
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CAS Number
[1343364-54-4]
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Molecular Formula
C11H15N5Na3O12P3
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Molecular Weight
571.15
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Smiles
O=P(O)([O])OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O)(O[Na])=O.[Na]
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Target
P2X Receptor
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Isoform
P2X1 Receptor; P2X3 Receptor; P2X7 Receptor
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Purity
99.75
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Solubility
H2O : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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α, β-Methylene-ATP (trisodium) [CAS 1343364-54-4]
α, β-Methylene-ATP (trisodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.