Methyltetrazine-SS-NHS

Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

C20H22N6O5S2

490.56

CC1=NN=C(C2=CC=C(CNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)C=C2)N=N1

ADC Linker

Cleavable Linker; Disulfide Cleavable Linker

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501