Metopimazine [CAS 14008-44-7]

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3].

[14008-44-7]

C22H27N3O3S2

445.6

O=C(N)C1CCN(CC1)CCCN2C3=C(SC4=CC=C(C=C24)S(=O)(C)=O)C=CC=C3

Dopamine Receptor

D2 Receptor

99.75

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302

H302