MHTT-IN-1 [CAS 2839311-21-4]

MHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD) . mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].

[2839311-21-4]

C18H19N7OS

381.45

O=C1C=C(C2=NN3C=C(C)N=C3C(C)=C2)N=C4SC(N5CCNCC5)=CN14

Huntingtin

10 mM in DMSO

Room temperature