MHuwentoxin-IV

MHuwentoxin-IV is a naturally modified Huwentoxin-IV. mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages[1].

C174H276N52O50S6

4088.76

O=C(NC(CC(C)C)C(N[C@H](CCC(O)=O)C(NC(C(C)CC)C(N[C@H](CC1=CC=CC=C1)C(NC(CCCCN)C(NC(C)C(NC(CSSCC(C(NC(CO)C(NC(CCCNC(N)=N)C(NC(CCCCN)C(NC(C(O)C)C(NC(CCCNC(N)=N)C(NC2CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC(N)=O)C(N6[C@@H](CCC6)C(NC(CO)C(NC(CC(N)=O)C(NC(CC(O)=O)C(NC(CCC(N)=O)C(NC7CSSCC(C(NC(CCCCN)C(NC(CC8=CC=C(C=C8)O)C(NC(CCC(N)=O)C(NC(C(C)CC)C(N)=O)=O)=O)=O)=O)NC2=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(NC([C@H]9NC(CC9)=O)=O)CSSCC(C(NC(CCCCN)C(NC(CO)C(NC(CO)C(NC(CCCCN)C(NC(CC(C)C)C(NC5C(C)C)=O)=O)=O)=O)=O)=O)NC7=O

Sodium Channel

10 mM in DMSO

Room temperature