MI-1061 [CAS 1410737-34-6]

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM) . MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].

[1410737-34-6]

C30H26Cl2FN3O4

582.45

O=C(O)C1=CC=C(NC([C@H](N2)[C@H](C3=CC=CC(Cl)=C3F)[C@]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1

Apoptosis; E1/E2/E3 Enzyme; MDM-2/p53

99.72

DMSO : 160 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature