MI-2-2 [CAS 1454920-20-7]

Name: MI-2-2 [CAS 1454920-20-7]
Brand: QuantiMol
SKU: QM-0112991-01
Price: 414.5 GBP
Availability: InStock

Size 5 mg 10 mM - 1 mL 10 mg 25 mg

SKU:QM-0112991-01

£414.50 GBP

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Product Details

Description
MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1].
CAS Number
[1454920-20-7]
Molecular Formula
C17H20F3N5S2
Molecular Weight
415.5
Smiles
FC(F)(F)CC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
Target
Epigenetic Reader Domain
Concentration
10mM
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Shipping Conditions
Blue Ice

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0112991-01	5 mgQM-0112991-01 £414.50/ea	£0.00	Quantity	£414.50/ea	£0.00

10 mM - 1 mLQM-0112991-02	10 mM - 1 mLQM-0112991-02 £450.95/ea	£0.00	Quantity	£450.95/ea	£0.00

10 mgQM-0112991-03	10 mgQM-0112991-03 £577.31/ea	£0.00	Quantity	£577.31/ea	£0.00

25 mgQM-0112991-04	25 mgQM-0112991-04 £1,029.29/ea	£0.00	Quantity	£1,029.29/ea	£0.00

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MI-2-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.