MI-888 (TFA) [CAS 1303609-30-4]

MI-888 (TFA) is an orally active MDM2-p53 interaction inhibitor with a Ki of 0.44 nM. MI-888 (TFA) can achieve rapid, complete, and sustained tumor regression in a xenograft mouse model of cancer[1].

[1303609-30-4]

C30H33Cl2F4N3O5

662.5

O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5C[C@](C)(O)C5.O=C(O)C(F)(F)F

MDM-2/p53

Room temperature