Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD) -induced PPARγ transcriptional activity (IC50=140 μM) . Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR) . Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].