Mitoxantrone (diacetate) [CAS 70711-41-0]

Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity[1][2][3][4]. Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].

[70711-41-0]

C26H36N4O10

564.58

O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.O=C(C)O.O=C(C)O

Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase

PKC; Topo II

10 mM in DMSO

Room temperature