MK-2461 [CAS 917879-39-1]

MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM) . MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM) . MK-2461 can be used for the study of cancer, such as gastric cancer[1].

[917879-39-1]

C24H25N5O5S

495.55

O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O

C-Met/HGFR

10mM

99.28

DMSO : ≥ 31 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H317, H319

H317, H319