ML786 [CAS 1237586-97-8]

ML786 is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=[1].

[1237586-97-8]

C29H29F3N4O3

538.56

O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2

Bcr-Abl; Discoidin Domain Receptor; Ephrin Receptor; Raf; RET; VEGFR

Room temperature