MLEB-22043

MLEB-22043 is a synthetic siderophore-monobactam conjugate that is taken up into bacteria via its synthetic siderophore component by TonB-dependent transporters. Once inside the bacteria, it exerts antibacterial activity through its β-lactam component. MLEB-22043 is a broad-spectrum antibiotic with significant inhibitory activity against Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa[1].

C26H27N9O11S2

705.68

NC1=NC(/C(C(N[C@]2([H])C(N(S(=O)(O)=O)[C@]2(C)[H])=O)=O)=N/OC(C)(C)C(NCC3=CN(CC(C(C=C(O)C(O)=C4)=C4O5)=CC5=O)N=N3)=O)=CS1

Antibiotic; Bacterial

Room temperature