MLKL-IN-3 [CAS 3031406-27-3]

MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM[1]. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

[3031406-27-3]

C31H29ClN4O6

589.04

ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O

Mixed Lineage Kinase; Necroptosis

10 mM in DMSO

Room temperature