MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM) . MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay) . MLS1547 acts as an antagonist for dopamine (DA) -stimulated β-arrestin recruitment to the D2R (IC50=9.9 μM) [1][2].
CAS Number
[315698-36-3]
Molecular Formula
C19H19ClN4O
Molecular Weight
354.83
Smiles
OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3
Target
Dopamine Receptor
Isoform
D2 Receptor
Concentration
10mM
Purity
99.94
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)