MM-589 (TFA) [CAS 2253167-09-6]

MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

[2253167-09-6]

C30H45F3N8O7

686.72

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.FC(C(O)=O)(F)F

WDR5

98.67

DMSO : ≥ 100 mg/mL

-20°C (Powder, sealed storage, away from moisture)

Blue Ice