MMP-9-IN-12

MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC) [1].

C28H24ClN3O5

517.96

COC1=C(OCC2=NN=C(C3=CC=CC=C3Cl)O2)C(C4)=C(C=C1)CC5N4CCC6=CC7=C(OCO7)C=C56

Apoptosis; MMP; Reactive Oxygen Species (ROS)

MMP-9

Room temperature