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MNS [CAS 1485-00-3]

MNS [CAS 1485-00-3]

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SKU:QM-0156939-01

£89.13 GBP
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  • Description

    MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells[1][2][3][4][5][6][7][8][9].

  • CAS Number

    [1485-00-3]

  • Molecular Formula

    C9H7NO4

  • Molecular Weight

    193.16

  • Smiles

    O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1

  • Target

    Integrin; NOD-like Receptor (NLR) ; Src; Syk

  • Isoform

    NLRP3

  • Concentration

    10mM

  • Purity

    99.6

  • Solubility

    DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H301, H315, H319, H335

  • Precautions

    H301, H315, H319, H335

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100 mgQM-0156939-01
100 mgQM-0156939-01
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10 mM - 1 mLQM-0156939-02
10 mM - 1 mLQM-0156939-02
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200 mgQM-0156939-03
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500 mgQM-0156939-04
500 mgQM-0156939-04
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MNS [CAS 1485-00-3]

MNS is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.