Mofarotene [CAS 125533-88-2]

Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells[1][2][3].

[125533-88-2]

C29H39NO2

433.63

CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)OCCN4CCOCC4)=CC=C2C(C)(CC1)C)C

Apoptosis; Caspase; Reactive Oxygen Species (ROS)

Caspase 3; Caspase 9

10 mM in DMSO

Room temperature