Mol4 [CAS 512800-53-2]

Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 μM) . Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia) [1].

[512800-53-2]

C30H20ClNO5S

542

O=C(C1=CC2=C(C(N(C3=CC=C(SC4=CC=C(C)C=C4)C=C3)C2=O)=O)C=C1)OCC(C5=CC=C(Cl)C=C5)=O

Bcl-2 Family

Room temperature