MPGES1-IN-7 [CAS 1268709-57-4]

MPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 μM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan in mice[1].

[1268709-57-4]

C23H34N4O

382.54

O=C(NC1CCCC1)C2CCN(CC2)C3=NC4=CC(C)=C(C=C4N3C(C)C)C

PGE synthase

99.78

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature