MPT0B392 [CAS 1346169-92-3]

MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line[1].

[1346169-92-3]

C19H20N2O6S

404.44

NC1=C2C(N=C(S(=O)(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C2)=CC=C1OC

Apoptosis; Caspase; JNK; Microtubule/Tubulin

Caspase; JNK

99.63

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice