MRC-G-001

MRC-G-001 is a Genipin derivative with an IC50 of 117 μM against A549 cancer cells. MRC-G-001 inhibits the phosphorylation of EGFR, JAK1, and STAT3, and modulates epithelial-mesenchymal transition (EMT) -related protein expression, thereby attenuating cell migration and invasion. MRC-G-001 induces cell cycle arrest and cell apoptosis. MRC-G-001 can be used for the study of cancers such as non-small-cell lung cancer[1].

C21H27NO4

357.44

[H][C@]12CC=C([C@]1([C@@H](OC=C2C(OC)=O)OC(C)C)[H])CNCC3=CC=CC=C3

Apoptosis; EGFR; JAK; STAT

JAK1; STAT3

Room temperature