MRL-650 [CAS 852315-00-5]

MRL-650 (CB1 inverse agonist 1), a chemical probe, is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].

[852315-00-5]

C25H18Cl3N3O3

514.79

CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O

Cannabinoid Receptor

CB1; CB2

10 mM in DMSO

Room temperature