MRS4719-d3

MRS4719-d3 is the deuterium labeled MRS4719. MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke[1].

C26H25D3N6O3S

507.62

CC[NH+](CC)CC.O=C(NC1=C2C=CC=CC2=CC=C1N3C4=C([2H])C(C([N-]5)=NOC5=S)=NC([2H])=C4[2H])CC3=O

Isotope-Labeled Compounds; P2X Receptor

Room temperature