Mrt-5702D

Mrt-5702D is a molecular glue degrader targeting cereblon (CRBN) . mrt-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. mrt-5702D is promising for research of G3BP2-related cancers (e.g., breast cancer, lung cancer) and neurodegenerative diseases[1].

C30H29ClN6O5S

621.11

C[C@H]1C2=CC=CC=C2C[C@H](N1S(=O)(CC3=CC=CC=C3Cl)=O)C(NCC4=CC5=NC=C(N5C=C4)N6CCC(NC6=O)=O)=O

Molecular Glues

Room temperature