MS4322 (isomer) [CAS 2601727-80-2]
MS4322 (isomer) [CAS 2601727-80-2]
SKU:QM-0147664-01
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Product Details
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Description
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand ; Blue: E3 ligase ligand HY-112078) ; Black: linker (HY-124780) ; E3+linker (HY-173093) ).
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CAS Number
[2601727-80-2]
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Molecular Formula
C55H76N10O12S
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Molecular Weight
1101.32
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Smiles
O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
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Target
Histone Methyltransferase; PROTACs
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Isoform
Cereblon; DOT1L; EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C; EZH1; EZH2; MDM2; NSD2/MMSET/WHSC1; PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8; SETD2/KMT3A; SETD7/KMT7; SETD8/KMT5A; SETDB1/KMT2G; SMYD2; SMYD3; SUV39H2/KMT1B; von Hippel-Lindau (VHL)
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Purity
95.32
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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MS4322 (isomer) [CAS 2601727-80-2]
MS4322 (isomer) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.