MS8815 [CAS 2855085-25-3]

MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC) [1].

[2855085-25-3]

C65H87N9O8S

1154.51

CC(C=C(C)N1)=C(CNC(C2=C(C)C(N(CC)C3CCOCC3)=CC(C4=CC=C(CN5CCN(C(CCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)=O)CC5)C=C4)=C2)=O)C1=O

Histone Methyltransferase; PROTACs

99.95

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice