MS9024

MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM) . MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM[1].

C21H22N6O2S

422.5

CCC1=C(C(SC(C2=CC=CC=C2)C(N)=O)=NC(N(CC(NC)=O)C)=C1C#N)C#N

DNA Methyltransferase

DNMT1

99.83

DMSO : 8.33 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature