MT-125 (free base) [CAS 2404652-80-6]

MT-125 free base is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki, NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM) . MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma[1].

[2404652-80-6]

C22H19N3O2

357.41

CC1=CC2=C(N=C(N(C3=CC4=C(N=C(C)C=C4)C=C3)CC5)[C@]5(O)C2=O)C=C1

Akt; ERK; Ferroptosis; mTOR; Myosin; PDGFR; Reactive Oxygen Species (ROS)

PDGFRα

98.66

4°C (Powder, sealed storage, away from moisture)

Room Temperature