MT-44 [CAS 2966790-70-3]

MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer[1].

[2966790-70-3]

C26H23N5O4

469.49

COC1=CC=C2OC(C3=CC=C4N=C(OC4=C3)N)=C/C(C2=C1)=N\C5=CC=CC=C5NC(CCN)=O

Apoptosis; mTOR; Reactive Oxygen Species (ROS) ; STING

Room temperature