Mtb-IN-12

Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that can target the CYP125 (KD: 40 nM; KI: 0.1 μM) and CYP142 (KD: 160 nM; KI: 0.05 μM) enzymes of Mycobacterium tuberculosis. Mtb-IN-12 exhibits good inhibitory activity against both drug-sensitive strains and multidrug-resistant tuberculosis strains, with low toxicity to macrophages. Mtb-IN-12 can be used in the research of anti-tuberculosis drugs[1].

C20H20N2O

304.39

COC1=CC=C(CNC2=CC=C(C=C2)CC3=CC=NC=C3)C=C1

Bacterial; Cytochrome P450

Room temperature