MtTMPK-IN-8 [CAS 2990619-92-4]

MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis[1].

[2990619-92-4]

C24H24N6O7

508.48

CC1=CN(C(NC1=O)=O)C2CCN(CC2)C3=CC=C(C=C3)CNC(C4=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C4)=O

Bacterial; Thymidylate Synthase

10 mM in DMSO

Room temperature