Mufemilast [CAS 1255909-03-5]

Mufemilast (Heymay005) is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor (IC50 = 80-120 nM) . Mufemilast modulates cytokines upregulated in Behςet’s syndrome (BS) . Mufemilast displays a significant inhibitory effect on TNF-α, which is an important proinflammatory cytokine target in the disease process of psoriasis. Mufemilast can be studied in research for diseases such as rheumatoid arthritis, psoriasis and BS[1][2][3][4][5].

[1255909-03-5]

C20H22N2O7S2

466.53

O=C1C2=C(NC(C)=O)SC=C2C(N1[C@@H](C3=CC(OCC)=C(C=C3)OC)CS(C)(=O)=O)=O

Phosphodiesterase (PDE)

PDE4

99.67

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature