Multi-kinase-IN-6 [CAS 3009081-73-3]
Multi-kinase-IN-6 [CAS 3009081-73-3]
SKU:QM-0072412
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Product Details
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Description
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].
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CAS Number
[3009081-73-3]
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Molecular Formula
C17H15N5O2
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Molecular Weight
321.33
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Smiles
COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
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Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; Casein Kinase; CDK; Checkpoint Kinase (Chk) ; c-Kit; EGFR; Pim; Trk Receptor
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Isoform
CDK2; Chk1; CK2; EGFR/ErbB1/HER1; PIM1; TrkA
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Multi-kinase-IN-6 [CAS 3009081-73-3]
Multi-kinase-IN-6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.