Multi-target kinase-IN-5
Multi-target kinase-IN-5
SKU:QM-0011740
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Product Details
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Description
Multi-target kinase-IN-5 (Compound 23) is an orally active ERK1/2 inhibitor (IC50 values are 3.04 nM and 1.57 nM, respectively) . Multi-target kinase-IN-5 significantly inhibits cancer cell proliferation, migration and invasion, and induces cell apoptosis and cell cycle arrest. Multi-target kinase-IN-5 inhibits the phosphorylation of ERK1/2 and downregulates the activity of its downstream substrate RSK to exert anti-tumor effects. Multi-target kinase-IN-5 can be used in cancer research[1].
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Molecular Formula
C20H18ClFN4O3
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Molecular Weight
416.83
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Smiles
O=C(C1=CC2=C(C=C1)C=NC(NC3COC3)=N2)N[C@H](CO)C4=CC=C(C(F)=C4)Cl
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Target
Apoptosis; ERK
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Shipping Conditions
Room temperature
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Multi-target kinase-IN-5
Multi-target kinase-IN-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.