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Mutant IDH1/NAMPT-IN-1 [CAS 3040122-14-0]
Mutant IDH1/NAMPT-IN-1 [CAS 3040122-14-0]
SKU:QM-0127372
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Product Details
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Description
Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC50=14.93 nM) and nicotinamide phosphoribosyltransferase (NAMPT) (IC50=12.56 nM) . Mutant IDH1/NAMPT-IN-1 can induce apoptosis. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively[1].
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CAS Number
[3040122-14-0]
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Molecular Formula
C30H29FN6O4
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Molecular Weight
556.59
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Smiles
C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)NC(COC3=CC=CN=C3)=O)NC4=NC(N5[C@H](COC5=O)[C@H](C)F)=CC=N4
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Target
Apoptosis; Isocitrate Dehydrogenase (IDH) ; NAMPT
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Isoform
IDH1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Mutant IDH1/NAMPT-IN-1 [CAS 3040122-14-0]
Mutant IDH1/NAMPT-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.