MXC-017 [CAS 3037024-97-5]

MXC-017 is a blood-brain barrier (BBB) -penetrant apoptosis inducer that directly targets Vimentin (VIM) . MXC-017 prevents radiation-induced glioma stem cell (GSC) formation, while promoting G0/G1 cell cycle arrest and apoptosis. MXC-017 exhibits minimal off-target effects and shows no significant cytotoxicity. MXC-017 significantly prolongs median survival when used in combination with radiation therapy in glioblastoma (GBM) mouse models.

[3037024-97-5]

C21H23N3O3S

397.49

O=C(NCC1=CC=C(S(=O)(N2CCCCC2)=O)C=C1)N3C4=CC=CC=C4C=C3

Apoptosis

Room temperature