MYC-RIBOTAC

MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research[1]. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 , RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

C55H58N10O11S

1067.17

O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7

Apoptosis; c-Myc; PROTACs

98.17

DMSO : 100 mg/mL (ultrasonic)

-20°C (Powder, protect from light)

Blue Ice