(–) -Mycousnine [CAS 77480-55-8]

(–) -Mycousnine is a microbial metabolite and derivative of Usnic Acid originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–) -Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).

[77480-55-8]

C19H20O8

376.36

CO[C@@](OC1=C2C(C)=O)(CC(O)=C3C(C)=O)[C@@](C1=C(C(C)=C2O)O)(C3=O)C

Fungal

Room temperature