MYF-03-176 [CAS 2857937-59-6]

MYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model[1][2][3].

[2857937-59-6]

C19H18F4N4O2

410.37

FC(F)(F)C1=CC=C(CO[C@@H]2CN(C(C(F)=C)=O)C[C@H]2NC3=NC=CC=N3)C=C1

YAP

99.72

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature