Myosin-IN-1 [CAS 849011-39-8]

Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1].

[849011-39-8]

C12H16N4OS2

296.41

O=C1C2=C(N=CN1NC(NC(C)C)=S)SC(CC)=C2

Myosin

10 mM in DMSO

Room temperature