Myt1-IN-4

Myt1-IN-4 (21) is an orally active and selective membrane-associated tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1) (Gene name PKMYT1) inhibitor, with an IC50 of 2.6 nM. Myt1-IN-4 (21) possesses antitumor activity[1].

C25H27N7O2

457.53

NC([N@@]1[C@@]2=C(C=CC(O)=C2C)C)=C(C3=NC(C4CC4)=C(N=C31)C)C(N5CCN6N=CC=C6C5)=O

Wee1

PKMYT1

10 mM in DMSO

Room temperature