N- (3-Oxohexanoyl) -L-homoserine lactone [CAS 143537-62-6]
N- (3-Oxohexanoyl) -L-homoserine lactone [CAS 143537-62-6]
SKU:QM-0205917-01
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Product Details
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Description
N- (3-Oxohexanoyl) -L-homoserine lactone (OHHL; N- (3-Oxohexanoyl) homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 μM. N- (3-Oxohexanoyl) -L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N- (3-Oxohexanoyl) -L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N- (3-Oxohexanoyl) -L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica[1][2][3].
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CAS Number
[143537-62-6]
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Molecular Formula
C10H15NO4
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Molecular Weight
213.23
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Smiles
CCCC(CC(N[C@@H]1C(OCC1)=O)=O)=O
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Target
Bacterial
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Purity
99.93
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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N- (3-Oxohexanoyl) -L-homoserine lactone [CAS 143537-62-6]
N- (3-Oxohexanoyl) -L-homoserine lactone is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.