N-Acetylgalactosaminyltransferase 1
N-Acetylgalactosaminyltransferase 1
SKU:QM-0161445
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Product Details
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Description
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3[1].
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Smiles
[N-Acetylgalactosaminyltransferase1]
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Target
Endogenous Metabolite; Wnt; β-catenin
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Solubility
10 mM in DMSO
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Storage Conditions
Store at -20°C for 2 years
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Shipping Conditions
Blue Ice
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N-Acetylgalactosaminyltransferase 1
N-Acetylgalactosaminyltransferase 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.